Na+/K+ ATPase

Sodium potassium pump

Na+/K+ ATPase

Related Products

Na⁺/K⁺ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na⁺/K⁺ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na⁺/K⁺-ATPase (NKA, or Na⁺ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Na+/K+ ATPase Related Products (101)
Antibodies (11)

By Effects:	Control (1) Inhibitors (75) Antagonist (1) Activators (11) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-170895

Hsp90-IN-38	Inhibitor
Hsp90-IN-38 (compound 20m) is a HSP90 (heat shock protein) inhibitor. Hsp90-IN-38 exhibits strong HSP90 binding affinity with a K_d of 87 nM. Hsp90-IN-38 inhibits ATPase with an IC₅₀ of 0.13 μM. Hsp90-IN-38 inhibits HCT116, MCF-7, SKBr3, K562 and A549 cells with IC₅₀s of 0.187, 0.072, 0.105, 0.403 and 031 μM, respectively.

HY-N0039R

Ginsenoside Rb1 (Standard)	Inhibitor
Ginsenoside Rb1 (Standard) is the analytical standard of Ginsenoside Rb1. This product is intended for research and analytical applications. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na⁺, K⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N1446R

Oleic acid (Standard)	Activator
Oleic acid (Standard) is the analytical standard of Oleic acid. This product is intended for research and analytical applications. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.

HY-N6745S

Citreoviridin-¹³C₂₃	Modulator
Citreoviridin-¹³C₂3 is ¹³C labeled 2,3-Pentanedione (HY-W012998). 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans.

HY-169036

1,2-Di-13(Z)-docosenoyl-3-oleoyl-rac-glycerol	Activator
1,2-Di-13(Z)-docosenoyl-3-oleoyl-rac-glycerol (1-Paimitin-2-olein-3-linolenin) is a triacylglycerol that contains 13(Z)-docosenoic acid at the sn-1 and sn-2 positions and Oleic acid (HY-N1446) at the sn-3 position.

HY-N0877R

Bufalin (Standard)	Inhibitor
Bufalin (Standard) is the analytical standard of Bufalin. This product is intended for research and analytical applications. Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively. Anti-cancer activity.

HY-17623S

Tegoprazan-d₆	Inhibitor
Tegoprazan (CJ-12420; RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC₅₀ values ranging from 0.29-0.52 μM for porcine, canine, and human H⁺/K⁺-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases.

HY-115312

Ro 18-5364
Ro 18-5364 is an inhibitor of gastric H+/K+ ATPase, which has the effect of inhibiting the activity of the enzyme. Ro 18-5364 has a very strong inhibitory effect on gastric mucosal H+/K+ ATPase, and the inhibitory effect is more significant at low pH. At the same time, there is no selectivity difference between the two enantiomers of H+/K+ ATPase, and its inhibitory effect can be studied and verified by a variety of experimental methods, including inhibition of enzyme activity, proton transport, and studies on its binding.

HY-170586

JAK05	Modulator
JAK05 exhibits inhibitory activity against Helicobacter pylori, inhibits strains J63, J196 and J107 with MIC of 3-5 µg/mL. JAK05 exhibits binding affinity to H+/K+-ATPase, COX-1/2, TNF-α and PGE2, reveals antioxidant and anti-inflammatory activities. JAK05 exhibits anti-ulcer activity in rat ethanol-induced gastric ulcer models.

HY-136933R

Gitoxin (Standard)	Inhibitor
Gitoxin (Standard) is the analytical standard of Gitoxin. This product is intended for research and analytical applications. Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably.

HY-N11690

Oleandrigenin	Inhibitor
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na⁺/K⁺-ATP-ase inhibiting and cytotoxic activities.

HY-N1446S4

Oleic acid-¹³C-1	Activator
Oleic acid-¹³C-1 is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.

HY-105094

Leminoprazole	Inhibitor
Leminoprazole (NC 1300O3) is an inhibitor for acid pump, H⁺ K⁺-ATPase,. Leminoprazole stimulates the secretion and synthesis of gastric mucus, attenuates gastric ulcers. Leminoprazole is orally active.

HY-P3711

SPAI-1	Inhibitor
SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na⁺, K⁺-ATPase and H⁺, K⁺-ATPase in vitro, stimulates Mg²⁺-ATPase.

HY-116050

17(S)-HETE	Inhibitor
17S-HETE is arachidonic acid metabolite through cytochrome P-450 pathways. 17S-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy.

HY-B0137B

Prilocaine acetate	Inhibitor
Prilocaine acetate, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine acetate has neurotoxic effects.

HY-N1446BR

Sodium oleate (Standard)	Activator
Sodium oleate (Standard) is the analytical standard of Sodium oleate. This product is intended for research and analytical applications. Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium[1]. Sodium oleate is a Na+/K+ ATPase activator[2].

HY-B0137R

Prilocaine (Standard)	Inhibitor
Prilocaine (Standard) is the analytical standard of Prilocaine. This product is intended for research and analytical applications. Prilocaine, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine has neurotoxic effects.

HY-W774926

Permethrin-d₆	Inhibitor
Permethrin-d₆ (NRDC-143-d₆) is deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes).

HY-N9456

14-Anhydrodigitoxigenin	Inhibitor
14-Anhydrodigitoxigenin is a cardenolides that can be isolated from the leaves of Acokanthera oblongifolia. 14-Anhydrodigitoxigenin is a Na^{+^/K⁺-ATPase} inhibitor.

Name
Email *

	Sorry, but the email address you supplied was invalid.

Na+/K+ ATPase

Na+/K+ ATPase

Na+/K+ ATPase Related Products (101)

Antibodies (11)

Na+/K+ ATPase Related Products (101):